ParkinsonCanadaV1, Main, Exploration, bibRecord, 000398

D3 dopamine receptor-preferring [11C]PHNO PET imaging in Parkinson patients with dyskinesia

Identifieur interne : 000398 ( Main/Exploration ); précédent : 000397; suivant : 000399

D3 dopamine receptor-preferring [11C]PHNO PET imaging in Parkinson patients with dyskinesia

Auteurs : Doris E. Payer ; Mark Guttman ; Stephen J. Kish ; Junchao Tong ; John R. Adams ; Pablo Rusjan ; Sylvain Houle ; Yoshiaki Furukawa ; Alan A. Wilson ; Isabelle Boileau

Source :

Neurology [ 0028-3878 ] ; 2016.

RBID : PMC:4733157

English descriptors

KwdEn :
- Aged, Carbon Radioisotopes, Case-Control Studies, Dopamine Agents (adverse effects), Dyskinesia, Drug-Induced (diagnostic imaging), Dyskinesia, Drug-Induced (etiology), Female, Globus Pallidus (diagnostic imaging), Humans, Levodopa (adverse effects), Male, Middle Aged, Neostriatum (diagnostic imaging), Parkinson Disease (diagnostic imaging), Parkinson Disease (drug therapy), Positron-Emission Tomography (methods), Receptors, Dopamine D2 (agonists), Receptors, Dopamine D2 (metabolism), Receptors, Dopamine D3 (agonists), Receptors, Dopamine D3 (metabolism), Up-Regulation, Ventral Striatum (diagnostic imaging).
MESH :
- chemical , adverse effects : Dopamine Agents, Levodopa.
- chemical , agonists : Receptors, Dopamine D2, Receptors, Dopamine D3.
- chemical , metabolism : Receptors, Dopamine D2, Receptors, Dopamine D3.
- chemical : Carbon Radioisotopes.
- diagnostic imaging : Dyskinesia, Drug-Induced, Globus Pallidus, Neostriatum, Parkinson Disease, Ventral Striatum.
- drug therapy : Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- methods : Positron-Emission Tomography.
- Aged, Case-Control Studies, Female, Humans, Male, Middle Aged, Up-Regulation.

Abstract

Objective:

To investigate whether levodopa-induced dyskinesias (LID) are associated with D₃ overexpression in levodopa-treated humans with Parkinson disease (PD).

Methods:

In this case-control study, we used PET with the D₃-preferring radioligand [¹¹C]-(+)-PHNO to estimate D_2/3 receptor binding in patients with levodopa-treated PD with LID (n = 12) and without LID (n = 12), and healthy control subjects matched for age, sex, education, and mental status (n = 18).

Results:

Compared to nondyskinetic patients, those with LID showed heightened [¹¹C]-(+)-PHNO binding in the D₃-rich globus pallidus. Both PD groups also showed higher binding than controls in the sensorimotor division of the striatum. In contrast, D_2/3 binding in the ventral striatum was lower in patients with LID than without, possibly reflecting higher dopamine levels.

Conclusions:

Dopaminergic abnormalities contributing to LID may include elevated D_2/3 binding in globus pallidus, perhaps reflecting D₃ receptor upregulation. The findings support therapeutic strategies that target and diminish activity at D₃ to prevent LID.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733157

DOI: 10.1212/WNL.0000000000002285
PubMed: 26718579
PubMed Central: 4733157

Affiliations:

Le document en format XML

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 dopamine receptor-preferring [<sup>11</sup>
C]PHNO PET imaging in Parkinson patients with dyskinesia</title>
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 dopamine receptor-preferring [<sup>11</sup>
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<term>Dyskinesia, Drug-Induced (etiology)</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Objective:</title>
<p>To investigate whether levodopa-induced dyskinesias (LID) are associated with D<sub>3</sub>
 overexpression in levodopa-treated humans with Parkinson disease (PD).</p>
</sec>
<sec><title>Methods:</title>
<p>In this case-control study, we used PET with the D<sub>3</sub>
-preferring radioligand [<sup>11</sup>
C]-(+)-PHNO to estimate D<sub>2/3</sub>
 receptor binding in patients with levodopa-treated PD with LID (n = 12) and without LID (n = 12), and healthy control subjects matched for age, sex, education, and mental status (n = 18).</p>
</sec>
<sec><title>Results:</title>
<p>Compared to nondyskinetic patients, those with LID showed heightened [<sup>11</sup>
C]-(+)-PHNO binding in the D<sub>3</sub>
-rich globus pallidus. Both PD groups also showed higher binding than controls in the sensorimotor division of the striatum. In contrast, D<sub>2/3</sub>
 binding in the ventral striatum was lower in patients with LID than without, possibly reflecting higher dopamine levels.</p>
</sec>
<sec><title>Conclusions:</title>
<p>Dopaminergic abnormalities contributing to LID may include elevated D<sub>2/3</sub>
 binding in globus pallidus, perhaps reflecting D<sub>3</sub>
 receptor upregulation. The findings support therapeutic strategies that target and diminish activity at D<sub>3</sub>
 to prevent LID.</p>
</sec>
</div>
</front>
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<tree><noCountry><name sortKey="Adams, John R" sort="Adams, John R" uniqKey="Adams J" first="John R." last="Adams">John R. Adams</name>
<name sortKey="Boileau, Isabelle" sort="Boileau, Isabelle" uniqKey="Boileau I" first="Isabelle" last="Boileau">Isabelle Boileau</name>
<name sortKey="Furukawa, Yoshiaki" sort="Furukawa, Yoshiaki" uniqKey="Furukawa Y" first="Yoshiaki" last="Furukawa">Yoshiaki Furukawa</name>
<name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name>
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<name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J." last="Kish">Stephen J. Kish</name>
<name sortKey="Payer, Doris E" sort="Payer, Doris E" uniqKey="Payer D" first="Doris E." last="Payer">Doris E. Payer</name>
<name sortKey="Rusjan, Pablo" sort="Rusjan, Pablo" uniqKey="Rusjan P" first="Pablo" last="Rusjan">Pablo Rusjan</name>
<name sortKey="Tong, Junchao" sort="Tong, Junchao" uniqKey="Tong J" first="Junchao" last="Tong">Junchao Tong</name>
<name sortKey="Wilson, Alan A" sort="Wilson, Alan A" uniqKey="Wilson A" first="Alan A." last="Wilson">Alan A. Wilson</name>
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La maladie de Parkinson au Canada (serveur d'exploration)

D3 dopamine receptor-preferring [11C]PHNO PET imaging in Parkinson patients with dyskinesia

D3 dopamine receptor-preferring [11C]PHNO PET imaging in Parkinson patients with dyskinesia

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
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